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Border irregularity in moles may be a sign of:

  1. Healthy skin

  2. Infection

  3. Malignant melanoma

  4. Allergic reaction

The correct answer is: Malignant melanoma

Border irregularity in moles may be a sign of malignant melanoma. The other options are incorrect because healthy skin would not have any irregularities, an infection would typically not present as a border change in a mole, and an allergic reaction would involve the entire skin, not just a specific mole. Malignant melanoma is a type of skin cancer that can be detected by changes in the size, shape, and border of a mole. It is important to monitor any changes in moles and consult a doctor if there is any suspicion of melanoma.